Senior Honors Projects, 2010-current

Title

An Attempt to Quantify the Perception of Frequency Changes in Mice

Date of Award

Spring 2016

Document Type

Dissertation/Thesis

Degree Name

Bachelor of Arts (BA)

Department

Department of Communication Sciences and Disorders

Advisor(s)

Lincoln Gray, Ph.D.

Mark Gabriele, Ph.D.

Christopher G. Clinard, Ph.D.

Abstract

The purpose of my Senior Honors Project is to determine the functional effect of the carefully patterned inputs into the inferior colliculus on auditory processing in mice, and eventually to understand how some important signaling molecules may affect hearing. Through the study of C57 mice, behavioral data was collected and evaluated to indicate whether mice have a consistent perception of frequency changes. This was done by presenting awake, alert mice with a series of tones and auditory startles. A prepulse cue consisting of a change from one frequency to another was presented prior to a startle stimulus to determine the amount of inhibition of the acoustic startle response in mouse. Contrary to expected results, as frequency changes got bigger, inhibition of the startle response decreased.

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