Senior Honors Projects, 2010-current

Preferred Name - First Author

Erica Hoogerland

Date of Award

Spring 2016

Document Type

Dissertation/Thesis

Degree Name

Bachelor of Science (BS)

Department

Department of Communication Sciences and Disorders

Advisor(s)

Lincoln C. Gray

Abstract

Presbycusis, or age-related hearing loss is a condition that affects approximately 40% of the population over 65 years of age (Gates & Mills, 2005). Studying the effects of EphA4 mutations (wild type, heterozygous, and homozygous) mice is fundamental in understanding the relationship between onset of age-related hearing loss, in both the mammalian population and the human population. In order to further understanding of age-related hearing loss, the researchers evaluated thirty-six mice in a preliminary study from two months to nine months of age. Following data analysis, the researchers confirmed the results by continuing a second round of testing. The hearing potential of nine mice in a longitudinal study evaluated thresholds, peak latencies and amplitudes of mice from six months of age to nine months of age. The researchers found a correlation between the delayed onset of hearing loss in the lower frequencies and broadband clicks of the heterozygous (EphA4lacZ/+) mice subject group. There is a positive relationship (r2 = 0.067, p < 0.001) between the dB Threshold analysis of the independent observers. Additionally, there is a positive relationship (r2 = 0.334, p < 0.001) between the independent observers’ data analyses of peak one latency. Based on a preliminary discussion with the director of the National Institute of Aging, there is reason to speculate a heterozygous advantage to delay the onset of age-related hearing loss.

Available for download on Wednesday, April 11, 2018

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