Senior Honors Projects, 2010-2019
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Date of Graduation
Spring 2016
Document Type
Thesis
Degree Name
Bachelor of Science (BS)
Department
Department of Chemistry and Biochemistry
Advisor(s)
Scott Lewis
Abstract
Previous studies show that 1,2-disubstituted cyclobutenes can be used in reaction with difluorocarbene to produce 1,3-difluorobenzenes. A pathway to the synthesis of these types of compounds is of interest due to their presence in fluoroquinolone antibacterials, resins, and insecticides. The synthesis is unique because the fluorine atoms from the difluorocarbene are not adjacent to each other when the ring expands to a benzene ring. This study focuses on the reaction of difluorocarbene with 1-phenyl-2-methylcyclobutene, which was synthesized in one-pot in 4 steps starting from 1-phenyl-1-propyne and zirconocene dichloride.
Recommended Citation
Menger, Ruth Felicitas, "The synthesis of 1,3-Difluoro-2-methyl-4-phenylbenzene from a one-pot reaction of Difluorocarbene and 1-Phenyl-2-methylcyclobutene" (2016). Senior Honors Projects, 2010-2019. 232.
https://commons.lib.jmu.edu/honors201019/232
Included in
Medicinal-Pharmaceutical Chemistry Commons, Organic Chemicals Commons, Organic Chemistry Commons
