Senior Honors Projects, 2010-current

Preferred Name - First Author

Kathryn C Brooks

Date of Award

Spring 2015

Document Type

Dissertation/Thesis

Degree Name

Bachelor of Science (BS)

Department

Department of Communication Sciences and Disorders

Advisor(s)

Lincoln Gray

Abstract

The purpose of my Honors Research Project was to assist Dr. Megan

Klingenberg in completing part of the research in her final dissertation project. Dr.

Klingenberg’s project was based off of a study done by Allen and Ison in 2010.

This study tested the auditory spatial acuity of mice using pre-pulse inhibition of

the startle reflex as the response for detecting the sound stimulus. The goal of

Dr. Klingenberg’s AuD project was “to explore the methodological, functional, and

genetic influences on sound localization using pre-pulse inhibition of the acoustic

startle response in mice”. Dr. Klingenberg’s project was broken into three

sections: the effect of the test chamber on acoustic startle responses, the effect

that the EphA4 mutation would have on the mouse’s ability to localize sound, and

the ability to use the acoustic startle response (ASR) to study efferent

processing. My role in the research was to work on the first goal of the project in

finding a chamber that would accurately reproduce Allen and Ison’s findings. In

this reflection, I will describe the basic terms used in the experiment, the

importance and benefits of working with mice in a research setting, the general

procedure of the experiment, the results from the various chambers, and a brief

description of my experience in the lab.

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