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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Date of Award

Spring 2012

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Department of Kinesiology

Abstract

Purpose: The purpose of this project was to examine the effects of acute garlic supplementation on fibrinolytic potential and the fibrinolytic response to exercise in young healthy trained males. Methods: 18 healthy trained males (Age = 20.9 ± 2.2 years, Height = 178 ± 7.7 cm, Weight = 75.5 ± 9.6 kg, VO2max = 59.8 ± 6.7 ml kg-1 min-1) performed a graded treadmill test to volitional exhaustion. Blood samples were taken at rest, within two minutes post-exercise, and one hour post-exercise. Participants were randomly assigned to ingest either 900 mg of powdered garlic or a placebo three hours before the exercise session. The supplement was distributed in a double-blind, crossover fashion. Participants repeated the protocol with the other treatment after a 14-day washout period. Paired t-tests were used to compare height, weight, resting hematocrit, VO2max, respiratory exchange ratio, and treadmill time between the two trials. A two-factor (treatment and time) repeated measures analysis of variance (ANOVA) was used to assess changes in tPA activity, tPA antigen, and PAI-1 activity. A priori statistical significance was set at P <0.05. Results: A significant difference was found between the two treatment conditions for absolute and relative VO2max. No significant differences were observed between the two treatment conditions for treadmill time or respiratory exchange ratio at VO2max. There was no main effect for treatment and no treatment x time interaction for any of the fibrinolytic variables examined. Conclusion: Acute garlic supplementation does not alter fibrinolytic potential or the fibrinolytic response to exercise in young healthy trained males. Acute garlic supplementation does, however, cause a small but statistically significant increase in VO2max. It remains unclear if this increase in VO2max is of functional importance.

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