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Date of Award
Master of Science (MS)
Department of Biology
Serotonergic neurons of the raphe pallidus area of the brainstem are involved in the cardiovascular responses to stress. However, the manner in which they mediate these responses is not well understood and severe abnormalities in this system have been associated with Sudden Infant Death Syndrome. In the current study, microinjections of muscimol and 8-OH-DPAT (GABAA and 5HT1A receptor agonists, respectively) into the raphe pallidus abolished the increase in mean arterial pressure and the tachycardiac responses following air jet, handing, and restraint stress that were observed following microinjections of artificial cerebrospinal fluid. The stress responses following muscimol microinjections suggest that this region of the brainstem was responsible for mediating cardiovascular responses to stress. The result of DPAT microinjections suggests that within this region of the brainstem, the serotonin system is responsible for these responses.
Le, Nhut Minh Pham, "Activation of GABAA and 5HT1A receptors in the raphe pallidus abolish the cardiovascular responses to stress in conscious rats" (2010). Masters Theses. 381.