Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Date of Graduation
Master of Science (MS)
Department of Kinesiology
Trent A. Hargens
Stephanie P. Kurti-Luden
Christopher J. Womack
Introduction: Lipoprotein-associated Phospholipase A2 (Lp-PLA2) is a protein produced by inflammatory cells in circulation and is associated with cardiovascular disease (CVD) risk. Prior research demonstrates that obstructive sleep apnea (OSA) leads to increased inflammation and is also related to CVD. Physical activity is known to reduce inflammation and risk for both CVD and OSA. However, Lp-PLA2 has yet to be examined in individuals with OSA who do not have any other pre-existing conditions nor has it been associated with chronic physical activity. The purpose of this study was to examine if there is a relationship between Lp-PLA2 mass and OSA. A secondary purpose of this study was to determine if physical activity levels have an impact on Lp-PLA2 mass.
Methods: A total of 39 subjects with an average BMI of 29.7 ±5.3 were screened for risk of OSA with an at home assessment device and placed into OSA and non-OSA groups. Data collected included anthropometric data, Lp-PLA2 mass, maximal oxygen uptake (VO2max), resting heart rate and blood pressure, heart rate variability, and an assessment of physical activity using an accelerometer.
Results: There was no significant difference in Lp-PLA2 mass between OSA and non-OSA groups (160.5 ±121.3 vs 124.7 ± 134.4 ng/mL). However, after taking the mean value for Lp-PLA2 mass and dividing subjects up into two groups, one above and one below the mean, the group with the higher Lp-PLA2 had greater waist circumference (87.8 ± 12.2 vs 100.1 ± 11.9 cm; P < 0.05), sedentary minutes (645.4 ± 161.3 vs 937.3 ± 219.1; P < 0.001), and light intensity physical activity minutes (187.9 ± 84.5 vs 94.6 ± 27.0; P = 0.002).
Conclusions: There appears to be no relationship between OSA and Lp-PLA2 mass aside from a positive correlation to sedentary minutes. However, when separated by mean Lp-PLA2 mass, it does appear that higher Lp-PLA2 is associated with waist circumference, sedentary time, and time in light activity. This indicates that there could be a relationship between physical activity behavior and Lp-PLA2, as a result of differing adiposity profile.
Clark, Kendall G., "Lipoprotein associated phospholipase A2 in individuals with obstructive sleep apnea" (2020). Masters Theses, 2020-current. 41.