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Objective: To determine if the type of graft, autograft versus allograft, contributes to graft failure in anterior cruciate ligament (ACL) reconstruction in young active patients. Design: Systematic literature review. Methods: Searches were done in PubMed and Google Scholar, utilizing the terms anterior cruciate ligament reconstruction, allografts and autografts. In PubMed the following filters and terms were used: published in the last 5 years, humans, cohort, randomized control trial, meta-analysis, and English. Results: The Pallis et al study was included because it compared allograft and autograft reconstruction in active, military cadets. The Li et al study was included because it included subjective and objective data, including imaging. The meta-analysis by Kraeutler et al was included because it compared the subjective and objective data which was included in the other two studies. Conclusion: The use of autograft versus allograft tissue in ACL reconstruction yielded no difference in subjective functional examinations, patient’s ability to return to previous activity level or difference in stability and integrity on physical exam. There is a significant difference in re-rupture rate suggesting a higher incidence of re-rupture with allograft tissues used in the reconstruction of the ACL.
Wollak M, Cohrs D. Autograft versus allograft failure in anterior cruciate ligament reconstruction of young athletic patients. JMU Scholarly Commons Physician Assistant Capstones. http://commons.lib.jmu.edu/pacapstones/14/. Published August 1, 2016.