Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Course Instructor

Abby Massey

Capstone Semester

Fall 2019

Date of Graduation



Objective: To compare the effectiveness of corticosteroids (CS) versus exclusive enteral nutrition (EEN), as induction therapy of Crohn’s disease to induce remission. Design: Systematic literature review. Methods: Searches were done in PubMed utilizing the terms: enteral nutrition therapy, exclusive enteral nutrition, inflammatory bowel disease, Crohn’s disease, corticosteroids, pediatric, nutrition, and steroids. Articles were excluded with patients > 18 years of age, confounding variables, inclusion of other treatment options, or physician discretion bias in selecting a treatment option. Results: Ultimately, three articles were included in our review. Two of three studies examined showed a statistically significant improvement in remission rates in patients receiving EEN with one study showing similar rates. Patients receiving EEN were also noted to have improved intestinal healing, improved growth, and decreased need for biologic agents compared to patients receiving CS treatment. Conclusion: EEN appears to be an effective and possibly more beneficial treatment option as it is associated with fewer adverse reactions, promotes intestinal healing, and has similar remission and relapse rates as CS. It cannot be confirmed that EEN will be the preferred induction therapy as the treatment choice must be individualized. Further studies must be done to expand knowledge on the topic. Cost effectiveness and patient compliance are drawbacks to EEN therapy.

Document Type


CapstonePosterFinal.pptx (626 kB)
Capstone Poster