Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Course Instructor

Abby Massey

Capstone Semester

Fall 2021

Date of Graduation



Objective: Assess the efficacy of subthalamic nucleus deep brain stimulation (STN DBS) versus solely optimal pharmacological use in early Parkinson's Disease to improve motor dysfunction. Design: Systematic Literature Review. Methods: Searches were completed on PubMed utilizing the MeSH terms: “subthalamic, deep brain stimulation, and early parkinson.” Using PubMed the following limits and terms were used: published in the last 10 years, randomized controlled trial, English, human, and removing duplicates. A total of three studies resulted after the search. Results: All three studies showed statistically significant results in reduction in disease progressive motor symptoms. Additionally, at the end of each study a lower dosage of levodopa was needed to control symptoms. Conclusion: STN DBS shows promising improvements in PD motor symptoms; however, the choice to undergo this treatment must be an individual conversation for each patient and their provider with a risk versus benefit analysis on a case-by- case basis. Further research is needed with great sample sizes and to assess long-term effects of STN DBS on patients with PD as the therapy is implemented years earlier than currently approved.

Document Type




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