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Objective: Assess the efficacy of subthalamic nucleus deep brain stimulation (STN DBS) versus solely optimal pharmacological use in early Parkinson's Disease to improve motor dysfunction. Design: Systematic Literature Review. Methods: Searches were completed on PubMed utilizing the MeSH terms: “subthalamic, deep brain stimulation, and early parkinson.” Using PubMed the following limits and terms were used: published in the last 10 years, randomized controlled trial, English, human, and removing duplicates. A total of three studies resulted after the search. Results: All three studies showed statistically significant results in reduction in disease progressive motor symptoms. Additionally, at the end of each study a lower dosage of levodopa was needed to control symptoms. Conclusion: STN DBS shows promising improvements in PD motor symptoms; however, the choice to undergo this treatment must be an individual conversation for each patient and their provider with a risk versus benefit analysis on a case-by- case basis. Further research is needed with great sample sizes and to assess long-term effects of STN DBS on patients with PD as the therapy is implemented years earlier than currently approved.
Reale EN, Legaluppi GN. Effects of subthalamic deep brain stimulation on treating motor symptoms in early parkinson's disease. 2021.