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Objective: To assess the effectiveness of MDMA-assisted psychotherapy in treating patients with chronic refractory PTSD using a systematic review.
Methods: Literature search was performed on PubMed and PsychINFO using search terms “PTSD” and “MDMA” to identify randomized control trials within the past 10 years.
Results: Two out of the three studies found statistically significant data in the treatment of refractory PTSD. Mithoefer, M. et al and Ot’alora, M. et. al found a statistically significant decrease in CAPS-IV total scores, decrease in depression symptoms, decreased in dissociative symptoms, and increase in sleep quality.
Conclusion: The use of MDMA-assisted psychotherapy may be beneficial in treating chronic PTSD patients who have failed previous treatment methods. Additional studies with a larger sample size are necessary to determine the efficacy of MDMA-assisted psychotherapy in treating chronic PTSD.
Blixt LN, Coleman AL. Efficacy of MDMA-Assisted Psychotherapy in the Treatment of Chronic PTSD. Posted online December 14, 2020.