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Course Instructor
Dr. Abigail Massey
Capstone Semester
Fall 2023
Date of Graduation
12-16-2023
Abstract
Objective: Assess the 5 year local recurrence rate of intraoperative radiotherapy (IORT) in relation to the conventional treatment of external breast radiotherapy (EBRT) in eligible females diagnosed with breast cancer over age 40.
Design: Systematic literature review.
Methods: PubMed was searched using the following limits and terms: breast neoplasms, intraoperative radiotherapy, randomized control trial, clinical trial, females, English, and published in the last 10 years.
Results: Three studies were found to directly compare IORT and EBRT regarding 5 year local recurrence rates.
Conclusion: IORT was shown to be non-inferior to EBRT in two of the three studies that were examined; more research is necessary to confidently establish this. The benefits of IORT, including convenience, length of treatment, and side effect profile, deem further study worthwhile. The full risk-benefit profile of both radiotherapy options should be discussed with eligible patients in shared decision-making tailored to each individual.
Document Type
Capstone
Recommended Citation
Oslund A, Schultz J. Investigation of the effectiveness of intraoperative radiotherapy in treatment of unifocal invasive breast cancer. Dec 2023.
IORT: the future of breast cancer treatment?
