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Date of Graduation
Master of Science (MS)
Department of Kinesiology
A single high-fat meal (HFM) can increase systemic inflammation (postprandial inflammation; PPI) and may be attenuated by recent exercise. However, the effect of preprandial exercise on PPI in older adults (OA) is not clear. Purpose: To determine if preprandial exercise attenuates PPI in YA and OA. Methods: 12 YA (23.3±3.9 years n= 5 M/7 F) and 12 OA (67.7±6 years, n= 8 M/4 F) completed two HFM challenges in a randomized order. During HFM alone, participants abstained from exercise 48 hours prior to the HFM session (except for the exercise session) and adhered to a 12 hour overnight fast. Baseline measurements were taken immediately before participants consumed the HFM (12 kcals/kg BW: 57% fat, 39% CHO, 4% PRO), and then again three and six hours postprandially. In exercise + HFM (EX+HFM) participants performed exercise at a heart rate that corresponded to 65% VO2Peak until caloric expenditure matched 75% of the caloric content of the HFM, then adhered to a 12 hour overnight fast before consuming the HFM. Results: All markers of inflammation were lower at three hours postprandially regardless of condition or age (ppp>0.05). TNFα was greater in OA at baseline compared to YA (pp>0.05). There was no difference in inflammation between HFM and EX+HFM at any time point (p>0.05). Conclusion: Contrary to our hypotheses, a HFM did not elicit PPI in YA or OA. Additionally, exercise did not impact inflammation at any timepoint. Future work should be performed on the PPI response and the effect of preprandial exercise on individuals already afflicted with inflammation related diseases.
Wisseman, William, "Does acute preprandial exercise modify postprandial inflammation after a high fat meal in young and older adults?" (2019). Masters Theses, 2010-2019. 631.