Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Date of Graduation

Fall 12-2019

Document Type


Degree Name

Master of Science (MS)


Department of Kinesiology


Elizabeth Edwards

Jeremy Akers

Trent Hargens


Increase prevalence of cardiovascular and other chronic diseases linked to inflammation has led to research on pro-inflammatory cytokines, like tumor necrosis factor - alpha (TNF-α) and lipoprotein-associated phospholipase A2 (Lp-PLA2), in attempt to define the relationship between chronic disease, inflammation, and obesity. PURPOSE: Examine the effect of twelve weeks of vigorous intensity interval training on pro-inflammatory markers in post-operative bariatric and obese participants. METHODS: 9 post-operative bariatric individuals [1 man, 8 women; Body mass index (BMI) = 34.23 ± 2.54 kg/m2], 12 obese individuals [5 men, 7 women; BMI=35.77 ± 1.67 kg/m2], and 13 obese individuals [5 men, 8 women; BMI=39.69 ± 1.74 kg/m2] were assigned into three groups: post-operative bariatric vigorous intensity interval training (PB-VIT), obese high intensity interval training (OB-VIT), moderate intensity continuous training (MICT), respectively. All groups underwent two weeks of familiarization on a treadmill maintaining 50% age adjusted heart rate reserve (HRR) for 20 minutes. Weeks 3-6, VIT performed 4 1-minute bouts at 80% HRR interspersed with 4 minutes at 50% HRR. Whereas, MICT increased to 60% HRR. Weeks 7-12 VIT increased intensity to 50% HRR for 3 minutes followed by 1 minute at 80% HRR for 6 rounds. MICT increased to 65% HRR for weeks 7-12. RESULTS: There were no significant changes from pre- to post-training in TNF-α (p=0.115) or Lp-PLA2 (p=0.318). There was a significant decrease in PB-VIT’s HDL (68.56 ± 20.00 vs. 59.89 ± 19.73; p=0.001). There were no changes in LDL-C, triglycerides, Hb-A1c, or total cholesterol within the three groups. Lean mass significantly increased in OB-VIT (56.82 ± 13.64 vs. 57.81 ± 13.34; p=0.006) with a reduction in %BF (43.29 ± 9.49 vs. 42.41 ± 9.54; p=0.029). OB-MICT also had significant reduction in %BF (47.23 ± 7.09 vs. 46.45 ± 6.99; p=0.008), but no change in overall weight. No other significant changes were observed in body composition or cardiorespiratory fitness. CONCLUSION: Vigorous interval training in post-operative bariatric and obese individuals did not elicit significant changes in Lp-PLA2 and TNF-α when performed 3 days a week for 12 weeks in response to either a moderate intensity continuous exercise or VIT exercise protocol.



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