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Date of Graduation
Master of Science (MS)
Department of Kinesiology
Increase prevalence of cardiovascular and other chronic diseases linked to inflammation has led to research on pro-inflammatory cytokines, like tumor necrosis factor - alpha (TNF-α) and lipoprotein-associated phospholipase A2 (Lp-PLA2), in attempt to define the relationship between chronic disease, inflammation, and obesity. PURPOSE: Examine the effect of twelve weeks of vigorous intensity interval training on pro-inflammatory markers in post-operative bariatric and obese participants. METHODS: 9 post-operative bariatric individuals [1 man, 8 women; Body mass index (BMI) = 34.23 ± 2.54 kg/m2], 12 obese individuals [5 men, 7 women; BMI=35.77 ± 1.67 kg/m2], and 13 obese individuals [5 men, 8 women; BMI=39.69 ± 1.74 kg/m2] were assigned into three groups: post-operative bariatric vigorous intensity interval training (PB-VIT), obese high intensity interval training (OB-VIT), moderate intensity continuous training (MICT), respectively. All groups underwent two weeks of familiarization on a treadmill maintaining 50% age adjusted heart rate reserve (HRR) for 20 minutes. Weeks 3-6, VIT performed 4 1-minute bouts at 80% HRR interspersed with 4 minutes at 50% HRR. Whereas, MICT increased to 60% HRR. Weeks 7-12 VIT increased intensity to 50% HRR for 3 minutes followed by 1 minute at 80% HRR for 6 rounds. MICT increased to 65% HRR for weeks 7-12. RESULTS: There were no significant changes from pre- to post-training in TNF-α (p=0.115) or Lp-PLA2 (p=0.318). There was a significant decrease in PB-VIT’s HDL (68.56 ± 20.00 vs. 59.89 ± 19.73; p=0.001). There were no changes in LDL-C, triglycerides, Hb-A1c, or total cholesterol within the three groups. Lean mass significantly increased in OB-VIT (56.82 ± 13.64 vs. 57.81 ± 13.34; p=0.006) with a reduction in %BF (43.29 ± 9.49 vs. 42.41 ± 9.54; p=0.029). OB-MICT also had significant reduction in %BF (47.23 ± 7.09 vs. 46.45 ± 6.99; p=0.008), but no change in overall weight. No other significant changes were observed in body composition or cardiorespiratory fitness. CONCLUSION: Vigorous interval training in post-operative bariatric and obese individuals did not elicit significant changes in Lp-PLA2 and TNF-α when performed 3 days a week for 12 weeks in response to either a moderate intensity continuous exercise or VIT exercise protocol.
Rood, Brittany, "Effects of a 12-week vigorous interval training intervention on pro-inflammatory markers in post-operative bariatric and obese participants" (2019). Masters Theses, 2010-2019. 640.