Preferred Name
Kristian Ponder
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Date of Graduation
Spring 2016
Document Type
Thesis
Degree Name
Master of Arts (MA)
Department
Department of Graduate Psychology
Advisor(s)
Jeff Dyche
Melanie Shoup-Knox
Daniel D. Holt
Abstract
The present study explores the relation between sleep restriction and alcohol use and the neural substrates that result from chronic behaviors. Accumulation of the transcription factors ΔFosB is suggested as a possible outcome of chronic behaviors, such as addiction. Sleep is discussed as possible mediating factor in the relationship between ΔFosB and chronic alcohol consumption. There were four experimental groups in this study: Control (C), Sleep Deprivation only (SD), Alcohol Exposure only (AO), and both sleep deprivation and alcohol exposure (B). Levels of ΔFosB accumulation in the Nucleus Accumbens (NAc) revealed a significant main effect of sleep deprivation, but no effect of alcohol. Chronic partial sleep deprivation increased ΔFosB in the NAc more robustly than alcohol. Because previous research indicates that ΔFosB is involved in epigenetic modification and neuronal signaling pathways of addiction, sleep deprivation may be implicated in addiction.
Recommended Citation
Ponder, Kristian, "The effects of chronic partial sleep deprivation and chronic voluntary alcohol consumption on ΔFos B accumulation" (2016). Masters Theses, 2010-2019. 82.
https://commons.lib.jmu.edu/master201019/82
Included in
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