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Objective: To conduct an analysis of literature that examined the effects of long-term proton pump inhibitors (PPIs) in adults 50 years and older on fracture risk. Methods: A literature search of the PubMed database using the terms “long-term use of PPIs” AND “fractures” Results: All 3 studies reported a statistically significant increased risk of fracture associated with long-term use of PPIs in both men and women over 50. None of the studies showed an increased risk of fracture with short-term PPI use. Conclusions: Health care providers should be informing their patients of the potential risk associated with long-term PPI use. While there was no increased risk associated with short-term use of PPIs, providers should be sure to only prescribe the medications when they are heavily indicated, especially if they are to be used long-term. We would also recommend that patients who will be on these mediations long-term be assessed for fall risk and have that taken into consideration as well.
Conforto A, Messer H. Long-Term Proton Pump Inhibitor Use and Effect on Risk of Fractures. JMU Scholarly Commons Physician Assistant Capstones. https://commons.lib.jmu.edu/pacapstones/43/. Published December 12, 2018.