Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Course Instructor

Abby Massey MD

Capstone Semester

Fall 2018

Date of Graduation



Objective: To compare the efficacy of crystalloid versus colloid solutions, specifically normal saline versus albumin, in decreasing mortality among patients with septic shock requiring resuscitation fluids in the intensive care unit (ICU) setting. Design: Systematic literature review. Methods: Research was conducted in PubMed and UpToDate, utilizing the search terms sepsis, septic shock, fluid resuscitation, colloids and crystalloids. Specifically, in PubMed, the following limits and terms were used: randomized control trial, human subjects, English, and within the last 7 years. Results: The Annane et al study found no significant difference in colloid fluid resuscitation versus crystalloid fluid resuscitation in the decreasing 28-day mortality in hypovolemic shock patients specifically in the ICU setting. The Finfer et al study found no significant difference between albumin and normal saline when assessing 28-day mortality and morbidity for patients in the ICU with severe sepsis. The Caironi et al study found no significant difference in albumin and crystalloids co-administration compared to crystalloids alone in 28-day mortality and morbidity outcomes for those with septic shock admitted to the ICU. Conclusion: The choice of fluid in aggressive resuscitation has no significant effect on patient mortality in those with septic shock in the intensive care unit (ICU).

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