Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Course Instructor

Abby Massey

Capstone Semester

Fall 2020

Date of Graduation




Objective:To assess the prevalence of hyperhomocysteinemia in Parkinson’s Disease (PD) and if this elevated serum level can be used as a predictive biomarker in risk assessment for the progression of cognitive decline in PD.

Design:Systematic Literature Review

Methods:A literature search was conducted through Google Scholar and Pubmed using phrases such as, “Parkinson's Disease”, and “homocysteine”, “Parkinson’s progression. Three articles, measuring serum homocysteine levels and cognitive functioning in PD patients, were selected, analyzed, and compared to assess for a relationship between homocysteine levels and cognitive decline in PD.

Results: Elevated homocysteine levels are associated with worse cognitive scores in some areas of neurocognitive testing in PD patients as compared to those with normal homocysteine levels.

Conclusion:Though study results do show an inversely proportional relationship between homocysteine serum levels and cognitive function, the presence of confounding variables within PD subjects, as well as, the unknown physiologic mechanism of homocysteine and neurons, makes it difficult to find a causal relationship between elevated homocysteine and neurocognitive function in PD.

Document Type




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