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Objective: To evaluate the use of paracetamol in the treatment of closure of patent ductus arteriosus (PDA), as well as to investigate the amount of adverse side effects. Design: Systematic literature review. Methods: Searches were done in PubMed and Google scholar, using the search terms Paracetamol for patent ductus arteriosus and alternative treatment patent ductus arteriosus. In PubMed the following limits and terms were used: randomized control trial, English, and secondary endpoints. Results: Randomized control trial studies by Dash et al., El-Mashad et al., and El-Farrash et al. were included based on inclusion/exclusion criteria of the meta-analysis and with secondary endpoints including adverse side effects. Conclusion: Paracetamol has been found to be as efficacious, however not superior, in the closure of PDA when compared to the use of non-steroidal anti-inflammatories such as indomethacin and ibuprofen.
Boykins T, Wilson CA. Paracetamol compared to NSAIDs as treatment for patent ductus arteriosus in neonates. James Madison University. 2021.