Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Date of Graduation
Objective: To assess the efficacy of plasma rich proteins (PRP) compared to placebo in the treatment of androgenetic alopecia (AGA).
Design: Systematic literature review
Methods: Searches were done in PubMed utilizing the terms PRP, plasma rich protein, autologous activated PRP, autologous activated plasma rich protein, androgenetic alopecia, placebo, hair count, hair density, hair follicles, hair loss, therapeutic effect, growth factors, dermatology, and regenerative medicine. Articles were excluded if they were published before 2013, involved animal studies, compared minoxidil only in their research, included only female participants, non-English articles, studies with no quantifiable data, review research articles, and injections besides the scalp
Results: A meta-analysis yielded five adequate articles meeting both the inclusion and exclusion criteria including 143 patients. All five studies resulted in beneficial outcomes and statistically significant results in patients treated with PRP.
Conclusion: PRP injections revealed clinically significant improvement in hair growth and density along with overall patient satisfaction. PRP injections were shown to be well tolerated with mild pain and without any major adverse effects
Comstock MD, Stephenson HE. The Effect of Platelet Rich Plasma on the Treatment of Androgenetic Alopecia Compared to Placebo. 2021.