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The purpose of this systematic literature review is to examine the efficacy of platelet rich-plasma (PRP) gel as a therapy for diabetic foot ulcers (DFUs). Infections in patients with diabetes, especially diabetic foot ulcers, are challenging to treat due to neurovascular compromise. Searches were done in PubMed utilizing the terms “diabetic foot ulcer”, “platelet rich plasma” and “autologous”. In PubMed, the following limits and terms were used: randomized control trial (RCTs), sample size greater than 30 participants, foot ulcers, and English. A meta-analysis revealed three studies meeting inclusion/exclusion criteria: Li et al, Gude et al, and Ahmed et al. The literature available demonstrates that autologous PRP gel is an effective treatment to increase DFU healing rate when compared to the current standard of care. Further studies may be necessary to determine long term outcomes and consequences of the use of autologous PRP gel.
Klein E, Paoletti D. The Use of Autologous PRP Gel for the Treatment of Diabetic Foot Ulcers. 2022