Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Capstone Semester

Fall 2023

Date of Graduation



Objective: To assess the effect of probiotic supplementation on clinical symptoms of major depressive disorder in adults. Design: Systematic literature review. Methods: Searches were performed on PubMed using the terms “adults with depression and probiotics”. The limits on PubMed were set to include randomized control trials, studies on adults, studies done within the last 10 years, studies done on patients that did not have depression, studies that did not use the Beck Depression Inventory, and studies that focused on other conditions. Results: Three studies were found that met search criteria: Reninghaus et al., Schaub et al., and Chahwan et al. Conclusion: The included studies showed a reduction in Beck Depression Index scores reflecting an improvement in clinical symptoms of depression. Therefore, probiotic supplementation should be considered as a possible adjuvant therapy for adults with major depressive disorder.

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