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Date of Graduation
12-12-2025
Semester of Graduation
Fall
Abstract
Objective: To compare clinical outcomes of surgical mitral valve replacement (SMVR) and TEER with MitraClip therapy in patients with secondary mitral regurgitation.
Methods: We performed a review of the literature of primary research comparing clinical outcomes of surgical mitral valve replacement (SMVR) and TEER with MitraClip therapy in patients with secondary mitral regurgitation. A preliminary search of the medical database PubMed was conducted in October 2024 using the terms mitral valve, secondary mitral regurgitation, transcatheter edge-to-edge repair, surgical candidacy, and comparative outcomes. Limits included “published in the last 15 years, humans, English, randomized controlled trials, and cohort studies.”
Results: After performing the search of the literature, three studies were selected. These studies included “MitraClip therapy and surgical edge-to-edge repair in patients with severe left ventricular dysfunction and secondary mitral regurgitation: mid-term results of a single-centre experience” 1 by De Bonis et al which was a prospective cohort study comparing efficacy and safety endpoints for those treated with TEER vs. surgery at four years. Search result selection also included “Percutaneous repair or surgery for mitral regurgitation,” 2 by Feldman et al which was a randomized controlled trial studying safety and efficacy endpoints at one year between groups treated with TEER and with surgery. Lastly, the literature selection included “Five-year outcomes of transcatheter reduction of significant mitral regurgitation in high-surgical-risk patients” 3 by Kar et al. This was a prospective study on the TEER group included in Feldman et al study, looking at the safety and efficacy endpoints after five years from treatment.
Conclusion: Though TEER with MitraClip placement is not yet a competitive alternative to surgery, it can be an effective option for patients who would not be good candidates for surgical replacement
Recommended Citation
Slater, Iain, and Jordan Maddra. “Comparing Transcatheter Edge-To-Edge Repair (MitraClip) to Surgical Approaches for Secondary Mitral Regurgitation.” James Madison University Physician Assistant Capstone Papers, 29 May 2025.
