Purpose: The purpose of this analysis was to identify key predictors which impact knowledge of the Human Papillomavirus vaccine in adults aged 21 to 45 in Virginia.

Methods: Data was collected from the Together for Health Virginia Population Surveys administered by Virginia Commonwealth University and the University of Virginia. Logistic regression was performed on data using the variables sex, age, rurality, race, education, income, occupation, and type of health insurance coverage.

Results: There was a statistically significant positive relationship between knowledge of the HPV vaccine and part-time occupation (OR: 4.288, CI: 1.492-13.325), younger age (OR: 2.31, CI: 1.088-4.905), and higher education (OR: 2.683, CI: 1.227-5.870). There was a statistically significant negative relationship between knowledge of the vaccine and being male (OR: 0.437, CI: 0.248-0.771), living in an urban area (OR: 0.511, CI: 0.267-0.977), and identifying in the lower income category (OR: 0.246, CI: 0.093-0.651).

Conclusion: This study identified 6 key predictors in knowledge of the HPV vaccine among adults in Virginia. Future studies should explore, in particular, the category of students and residents of urban areas. Despite these results, knowledge of the HPV vaccine does not translate to intention to receive the vaccine. Therefore, future studies should additionally study attitudes, behaviors, and potential barriers.

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