The effect of acute aerobic exercise on hemostasis in obstructive sleep apnea patients

Author

Ryan A. Martin, James Madison UniversityFollow

Preferred Name

Ryan Martin

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Date of Graduation

Spring 2016

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Department of Kinesiology

Advisor(s)

Christopher J. Womack

Trent Hargens

Kent Todd

Abstract

Purpose: To determine the hemostatic response after acute aerobic exercise in Obstructive Sleep Apnea (OSA). Methods: Eighteen males were recruited from the university and local community. Individuals who presented evidence of cardiovascular, pulmonary, or metabolic disease were excluded. Apnea-Hypopnea Index (AHI) > 5 was criteria for OSA. Subjects performed a treadmill exercise test at 35% and 70% predicted VO₂reserve during the morning hours. Pre exercise blood samples were obtained after 15 minutes supine rest and within two minutes following exercise. Repeated Measures ANOVA were performed for Factor VIII antigen, tPA antigen, tPA activity, and PAI-1 activity across two time points (Pre vs. Post) and between conditions (OSA vs. Controls). Correlational analysis compared all hemostatic factors with age, BMI, and AHI. Results: Mean AHI was (13.00 + 12.6) indicating mild OSA severity. There were no exercise x condition interaction for any observed hemostatic markers (P > 0.05). There was a significant main effect for exercise in Factor VIII, tPA antigen, and tPA activity in both groups (P < 0.05). There was no main effect for OSA except an observed trend in PAI-1 which remained elevated after exercise (P = 0.05). FVIII:Ag and BMI (R = .520), tPA:Ag and AHI (R = .489), and tPA:Ag and age (R = .496) were positively correlated (P < 0.05). Conclusion: The hemostatic response after acute aerobic exercise is unaffected in mild OSA although PAI-1 activity seems to be elevated impacting fibrinolytic potential. BMI seems to correlate with FVIII:Ag, while AHI and age correlate with tPA:Ag.

Recommended Citation

Martin, Ryan A., "The effect of acute aerobic exercise on hemostasis in obstructive sleep apnea patients" (2016). Masters Theses, 2010-2019. 88.
https://commons.lib.jmu.edu/master201019/88