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Course Instructor
Abby Massey
Capstone Semester
Fall 2021
Date of Graduation
12-17-2021
Abstract
Objective: To determine the effects of probiotics on glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) in patients with Type II Diabetes (T2DM) controlled with oral medications. Design: Systematic Literature Review. Methods: Searches were conducted on PubMed using the terms: prebiotic, probiotic, type 2 diabetes, non-insulin dependent, and microbiota. Searches refined with parameters for Randomized Control Trials, written in English, and available texts. Results: Firouzi et al. did not show a significant change in the FBG between groups and a decrease in the HbA1c in the intervention group. Ejtahed et al. showed a significant decrease in both FBG and HbA1c from the placebo group to the intervention group. Asemi et al. showed that probiotics prevented a rise in both FBG and decreased HbA1c in the intervention group (though not significantly). Conclusion: FBG was found to be an inconsistent indicator of the effectiveness of probiotics for T2DM management. However, HbA1c levels were consistently lower in the intervention groups compared to control groups. While statistical significance was shown, clinical significance and extrapolation to a US population is inconclusive based on this review. The results are promising, but further studies with longer durations and a US population should be conducted.
Document Type
Capstone
Recommended Citation
Kime RC, Siford KD. DMII Bugging You? Probiotics May Help Reach Your Glycemic Goals. 2022
Poster
