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Date of Graduation
12-13-2024
Semester of Graduation
Fall
Abstract
Objective: Assess the effectiveness of microfragmented adipose tissue injections at lowering knee injury and osteoarthritis outcome scores (KOOS) 6 months post treatment in patients aged 18-75 with symptomatic knee osteoarthritis compared to platelet rich plasma injections. Design: systematic literature review. Methods: A search of PubMed and Google Scholar was performed using the terms “Lipogems”, “adipose tissue injection”, “Micro Fragmented adipose tissue injections”, “Micro Fragmented adipose tissue and PRP”, and “MFAT vs. PRP knee”. The search was limited to randomized controlled trials (RCTs) published in the past ten years. Results: Three randomized control trials (RCTs) met inclusion and exclusion criteria: two RCTs comparing PRP to MFAT injections were analyzed and a third article was selected that compared PRP + HA to MFAT injections. Two additional studies were included for background information. Conclusion: MFAT injections are a safe and viable option for patients with symptomatic OA. However, MFAT did not prove superior to PRP in lowering KOOS scores 6 months post treatment.
Recommended Citation
Bernot A, Colantonio E. A New Treatment for Knee Osteoarthritis: Microfragmented Adipose Tissue Injections. James Madison University Physician Assistant Program Capstone 2024. Published online December 11, 2024.
