Senior Honors Projects, 2010-current

Date of Award

Fall 2016

Document Type

Thesis

Degree Name

Bachelor of Science (BS)

Department

Department of Kinesiology

Advisor(s)

Dr. Christopher Womack

Abstract

PURPOSE: To assess the hemostatic responses to exercise in a patient with Polycythemia Vera (PV). METHODS: Six female runners (≥15 miles/week) completed a maximal treadmill test. One subject had PV while the other five subjects made up the comparison group. Blood samples were taken before and within two minutes after exercise. VO2max was also recorded. RESULTS: Pre-exercise Factor VIII and tPA-antigen were similar in the PV subject and comparison group. Factor VIII and tPA-antigen increased dramatically in the PV subject (+100%, +1000%) in relation to the comparison group (+22.9 ± 8.7%, +108 ± 78%) after exercise. Pre-exercise PAI-1 was lower in the PV subject and also decreased slightly more (-100%) in response to exercise than the comparison group (-43 ± 67%). CONCLUSIONS: Factor VIII, tPA-antigen, and PAI-1 responses to exercise are more dramatic in a Polycythemia Vera patient than in those without the disorder.

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