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Date of Graduation
5-14-2026
Semester of Graduation
Spring
Degree Name
Doctor of Audiology (AuD)
Department
Department of Communication Sciences and Disorders
First Advisor
Lincoln C. Gray
Second Advisor
Nikki A. Go
Third Advisor
Yingjiu X. Nie
Abstract
In informational masking (IM), random off-frequency background tones degrade pure-tone detections19. Conversely, in stochastic resonance (SR), the addition of some background sounds can enhance detection of a signal15. To our knowledge neither informational masking nor stochastic resonance have been studied in mice. Prepulse inhibition was used to determine the detection of a target signal in various background conditions with stable and variable off-frequencies, and thus the occurrence of IM and SR among wild-type, heterozygous, or mutated homozygous mice for the fractalkine receptor signaling protein (CX3CR1-GFP) thought to be a possible cause of Autism Spectrum Disorder (ASD)5. It was found that IM and SR occur in mice; SR only occurring in mice without the mutation. These findings are consistent with other animal studies of informational masking3, 7 and propose an effect of ASD on central auditory processes.
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