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Date of Award
Bachelor of Science (BS)
Department of Mathematics and Statistics
Various studies have identified the chicken embryo (Gallus gallus) as a useful model to study the retinogenesis process in humans. This project uses data from two specific RNA sequencing (RNA-seq) studies to investigate retina developmental biology. These studies are done in two different labs using different protocols, as such they cannot be compared directly. Study 1 contains chicken retina samples from embryonic day 3, 5 and 8; while study 2 has retina samples from embryonic day 8, 16, and 18 of developmental age. We apply a normalization method on both studies to account for differences in the two studies. In this work, we perform gene expression analysis on the transformed data to identify genes that could affect the retina development process.
Szvetecz, Sarah, "Combining chicken retina RNA-seq data across studies to strengthen biomarker detection" (2019). Senior Honors Projects, 2010-current. 720.