Senior Honors Projects, 2010-2019
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Date of Graduation
Spring 2019
ORCID
https://orcid.org/0000-0002-6773-2594
Document Type
Thesis
Degree Name
Bachelor of Science (BS)
Department
Department of Mathematics and Statistics
Advisor(s)
Nusrat Jahan
Abstract
Various studies have identified the chicken embryo (Gallus gallus) as a useful model to study the retinogenesis process in humans. This project uses data from two specific RNA sequencing (RNA-seq) studies to investigate retina developmental biology. These studies are done in two different labs using different protocols, as such they cannot be compared directly. Study 1 contains chicken retina samples from embryonic day 3, 5 and 8; while study 2 has retina samples from embryonic day 8, 16, and 18 of developmental age. We apply a normalization method on both studies to account for differences in the two studies. In this work, we perform gene expression analysis on the transformed data to identify genes that could affect the retina development process.
Recommended Citation
Szvetecz, Sarah, "Combining chicken retina RNA-seq data across studies to strengthen biomarker detection" (2019). Senior Honors Projects, 2010-2019. 720.
https://commons.lib.jmu.edu/honors201019/720
