Senior Honors Projects, 2010-current

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Date of Graduation

Spring 2019

ORCID

https://orcid.org/0000-0002-6773-2594

Document Type

Thesis

Degree Name

Bachelor of Science (BS)

Department

Department of Mathematics and Statistics

Advisor(s)

Nusrat Jahan

Abstract

Various studies have identified the chicken embryo (Gallus gallus) as a useful model to study the retinogenesis process in humans. This project uses data from two specific RNA sequencing (RNA-seq) studies to investigate retina developmental biology. These studies are done in two different labs using different protocols, as such they cannot be compared directly. Study 1 contains chicken retina samples from embryonic day 3, 5 and 8; while study 2 has retina samples from embryonic day 8, 16, and 18 of developmental age. We apply a normalization method on both studies to account for differences in the two studies. In this work, we perform gene expression analysis on the transformed data to identify genes that could affect the retina development process.

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Biostatistics Commons

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